Current Portfolio of Eosomes
Eos Biosciences’ internal drug development program is currently focused on applying the Eosomes technology to treating cancer. To that end, we have engineered two classes of Eosomes that collectively target a large variety of solid tumors using two receptors that are highly expressed on invasive, metastatic, and drug-resistant tumors:
- HER 3-targeted Eosomes
HER3 is a Human Epidermal Growth Factor Receptor over-expressed on many types of tumors and drug-resistant tumors. Heregulin is the identified natural ligand for HER3
- c-Met-targeted Eosomes
c-Met is the Receptor Tyrosine Kinase (RTK) expressed on cells of endothelial-epithelial origin.
c-Met is over-expressed on many types of tumors. Hepatocyte Growth Factor is the identified natural ligand for c-Met
Both classes of Eosomes have been tested with a variety of therapeutics in laboratory assays using cell cultures and mouse models for cancer